Serveur d'exploration Phytophthora

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Synthesis of sulfonate derivatives of carvacrol and thymol as anti-oomycetes agents.

Identifieur interne : 000040 ( Main/Exploration ); précédent : 000039; suivant : 000041

Synthesis of sulfonate derivatives of carvacrol and thymol as anti-oomycetes agents.

Auteurs : Gen-Qiang Chen [République populaire de Chine] ; Di Sun [République populaire de Chine] ; Jin-Ming Yang [République populaire de Chine] ; Song Zhang [République populaire de Chine] ; Yue-E Tian [République populaire de Chine] ; Zhi-Ping Che [République populaire de Chine] ; Sheng-Ming Liu [République populaire de Chine] ; Jia Jiang [République populaire de Chine] ; Xiao-Min Lin [République populaire de Chine]

Source :

RBID : pubmed:32406756

Abstract

Two series of sulfonate derivatives of carvacrol and thymol were synthesized and screened in vitro for their anti-oomycete activity against Phytophthora capsici, respectively. Among all of 32 derivatives, five compounds 3a, 4a, 4k, 3n, and 4n exhibited more potent anti-oomycete activity against P. capsici with EC50 values of 66.66, 62.94, 68.65, 61.24, and 52.91 mg/L, respectively. This suggested that introduction of different substitutions at the hydroxyl position of 1/2 could have remarkable effect on anti-oomycete activity. Overall, when R1 = isopropyl and R2 = methyl, the anti-oomycete activities of the compounds were higher than that of the corresponding compounds of R1 = methyl and R2 = isopropyl.[Formula: see text].

DOI: 10.1080/10286020.2020.1758675
PubMed: 32406756


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">Two series of sulfonate derivatives of carvacrol and thymol were synthesized and screened
<i>in vitro</i>
for their anti-oomycete activity against
<i>Phytophthora capsici</i>
, respectively. Among all of 32 derivatives, five compounds
<b>3a</b>
,
<b>4a</b>
,
<b>4k</b>
,
<b>3n,</b>
and
<b>4n</b>
exhibited more potent anti-oomycete activity against
<i>P. capsici</i>
with EC
<sub>50</sub>
values of 66.66, 62.94, 68.65, 61.24, and 52.91 mg/L, respectively. This suggested that introduction of different substitutions at the hydroxyl position of
<b>1</b>
/
<b>2</b>
could have remarkable effect on anti-oomycete activity. Overall, when R
<sup>1</sup>
= isopropyl and R
<sup>2</sup>
= methyl, the anti-oomycete activities of the compounds were higher than that of the corresponding compounds of R
<sup>1</sup>
= methyl and R
<sup>2</sup>
= isopropyl.[Formula: see text].</div>
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<i>in vitro</i>
for their anti-oomycete activity against
<i>Phytophthora capsici</i>
, respectively. Among all of 32 derivatives, five compounds
<b>3a</b>
,
<b>4a</b>
,
<b>4k</b>
,
<b>3n,</b>
and
<b>4n</b>
exhibited more potent anti-oomycete activity against
<i>P. capsici</i>
with EC
<sub>50</sub>
values of 66.66, 62.94, 68.65, 61.24, and 52.91 mg/L, respectively. This suggested that introduction of different substitutions at the hydroxyl position of
<b>1</b>
/
<b>2</b>
could have remarkable effect on anti-oomycete activity. Overall, when R
<sup>1</sup>
= isopropyl and R
<sup>2</sup>
= methyl, the anti-oomycete activities of the compounds were higher than that of the corresponding compounds of R
<sup>1</sup>
= methyl and R
<sup>2</sup>
= isopropyl.[Formula: see text].</AbstractText>
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